Thermo Fisher Scientific Inc. provides technologies and pharmaceutical services for pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as environmental, industrial quality and process control settings worldwide.
The company offers its products and services under Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon, and PPD brands.
The company operates through four segments: Life Sciences Solutions, Analytical Instruments, Specialty Diagnostics, and Laboratory Products and Biopharma Services.
Life Sciences Solutions segment
This segment provides a portfolio of reagents, instruments and consumables used in biological and medical research, the discovery and production of new drugs and vaccines, as well as the diagnosis of infection and disease. These products and services are used by customers in pharmaceutical, biotechnology, agricultural, clinical, healthcare, academic, and government markets. This segment includes four primary businesses – Biosciences, Genetic Sciences, Clinical Next-Generation Sequencing, and BioProduction.
The company’s biosciences business includes reagents, instruments and consumables that help its customers conduct biological and medical research, discover new drugs and vaccines, and diagnose infection and disease, such as COVID-19. Its biosciences offerings include:
Reagents, instruments, and consumables used for protein biology, molecular biology, sample preparation and cell imaging and analysis. The portfolio includes antibodies and products for protein purification, detection, modification, and analysis; and sequencing, detection and purification products used for high content analysis of nucleic acids. Majority of these products are also used in applied markets, including agriculture, forensics, diagnostics product development, toxicology research and diagnostic testing.
Tools used for genetic engineering, amplification, quantification and analysis, as well as RNA isolation, including stem cell reprogramming kits, transfection reagents, RNA interference reagents, along with gene editing tools and gene synthesis products.
Cell culture media, reagents, and plastics for preserving and mammalian cells, which are used in various life science research applications.
Fluorescence-based technologies, which facilitate the labeling of molecules for biological research and drug discovery. These technologies include a range of cell analysis instruments, including flow cytometers and imaging platforms that enable fluorescence microscopy.
Protein analysis products, including pre-cast electrophoresis gels for separating nucleic acids and proteins, and western blotting and staining tools.
The company’s genetic sciences business combines various instruments and related reagents used to provide high-value genomic solutions to assist customer decisions in the research, clinical, healthcare and applied markets. Its offerings include real-time polymerase chain reaction (PCR) technology used to identify changes in gene expression, genotyping or proteins on an individual gene-by-gene basis and for diagnostic testing to identify infection and disease, such as COVID-19; capillary electrophoresis sequencing, a core technology used in DNA sequencing and fragment analysis and forensic analysis applications; and microarray technology, used in gene expression, genotyping and reproductive health. The company’s genetic analyzers served as the foundational platform used to sequence the first human genome. These systems are used in various basic, commercial and clinical research applications.
Clinical Next-Generation Sequencing
The company’s clinical next-generation sequencing (NGS) business focuses on delivering NGS technology for a range of applications. The business focuses on targeted sequencing solutions for research use, the application of NGS in oncology and companion diagnostics.
The company’s bioproduction business supports developers and manufacturers of biological-based therapeutics and vaccines with a portfolio of premium solutions and services focused on upstream cell culture, downstream purification, analytics for detection and quantitation of process/product impurities, and a suite of single-use solutions spanning the biologics workflow. The company’s bioproduction offerings include:
Single-use bioproduction solutions that provide its customers with faster turnaround and set-up times, minimal validation requirements, reduced investment and running costs, and flexibility of manufacturing capacity.
Production cell culture media solutions, which are used by biotechnology and pharmaceutical companies to grow cells in controlled conditions and enable large scale Current Good Manufacturing Practices (cGMP) manufacturing of drugs and vaccines. The company also provides its customers with the associated services to optimize the productivity of these production platforms.
Chromatography products, which deliver superior capacity and resolution for process-scale bioseparations, and offer a broad set of scalable options for the purification of antibodies, antibody fragments and proteins.
Rapid molecular products that deliver accurate results in less than four hours for contaminant detection, identification and quantitation.
Scalable solutions for the manufacture of cell therapy-based drugs.
The company’s Doe & Ingalls offerings include chemical distribution and supply chain services that provide primarily life science manufacturers with reliable, secure supply chains for their chemical raw materials.
Analytical Instruments segment
This segment provides an offering of instruments, consumables, software and services that are used for a range of applications in the laboratory, on the production line and in the field. These products and services are used by customers in pharmaceutical, biotechnology, academic, government, environmental, and other research and industrial markets, as well as the clinical laboratory. This segment includes three primary businesses – Chromatography and Mass Spectrometry, Chemical Analysis, and Materials and Structural Analysis.
Chromatography and Mass Spectrometry
The company’s chromatography and mass spectrometry (MS) business provides analytical instrumentation for organic and inorganic sample analysis across both applied technologies and life science research. These products are complemented by laboratory information management systems (LIMS); chromatography data systems (CDS); database analytical tools; automation systems; a range of consumables, such as a line of chromatography columns; and a range of sample preparation and separation products, including auto-samplers and multiplexing systems.
Chromatography is a technique for separating, identifying and quantifying individual chemical components of substances based on their specific physical and chemical characteristics. The company’s chromatography product line includes liquid chromatography, ion chromatography and gas chromatography systems, all of which are supported by its Chromeleon chromatography data system software.
Liquid Chromatography (LC) Systems analyze complex sample matrices in liquids. The company’s high-pressure liquid chromatography (HPLC) and ultrahigh pressure liquid chromatography (UHPLC) systems offer high throughput and sensitivity; and are sold either as systems or integrated with its mass spectrometers (LC/MS and LC/MS/MS). These systems are used for a range of applications, from complex proteomic analyses to routine industrial quality assurance and quality control (QA/QC).
Ion Chromatography (IC) Systems separate ionic (charged) or highly polar molecules (sugars and carbohydrates), usually found in water-based solutions, and typically detect them based on their electrical conductivity. The company’s IC products are used in a range of applications, including scientific research, and environmental testing, as well as quality control in pharmaceutical, food and beverage, and other industrial processes.
Gas Chromatography (GC) Systems analyze complex sample matrices in gases, comprising both separation and detection technology. Separation technology is common to all gas chromatography analyzers, and is paired with either a conventional detector (GC) or with different types of mass spectrometers (GC/MS). The company’s GC/MS offering includes a triple stage quadrupole, a single stage quadrupole, an Orbitrap, and an ion trap, for a range of applications, including food safety testing, quantitative screening of environmental samples, and complex molecular analyses.
Elemental Analysis Spectrometers use atomic spectroscopy techniques to identify trace concentrations of elements in liquid and solid samples primarily in environmental, petrochemical, food safety, metallurgical, geochemical and clinical/toxicology research applications. These products are used in growth markets, such as China, India, and Latin America to support compliance with increasingly stringent international environmental and consumer safety regulations.
The company’s offering includes life sciences mass spectrometry systems; and inorganic mass spectrometry systems, as well as a range of sample preparation and separation products, including auto-samplers and multiplexing systems.
Life Sciences Mass Spectrometers include triple quadrupole and Orbitrap technologies. The company’s triple quadrupole systems provide quantitative analysis of chemicals in biological fluids, environmental samples and food matrices. They are also used by the pharmaceutical industry for targeted quantitation during drug discovery. The company’s Orbitrap technologies provide high resolution and mass capabilities for both research and applied markets; and are suited for drug metabolism, proteomics, environmental analysis, food safety, toxicology and clinical research applications. The company also offers a portfolio of instrument control and data analysis software to help customers simplify their workflows and obtain knowledge from often complex data.
Inorganic Mass Spectrometers include four product lines, such as isotope ratio mass spectrometry (IRMS); multi-collector isotope ratio mass spectrometry (MC/IRMS); inductively coupled plasma mass spectrometry (ICP/MS); and high resolution trace mass spectrometry (HR Trace/MS). These products are primarily used for qualitative and quantitative analysis of inorganic matter in a range of applications, including environmental analysis, materials science and earth sciences.
The company’s chemical analysis products fall into three main categories, including materials and minerals instruments; field safety instruments; and environmental and process instruments. Customers use these products to analyze the composition of materials to optimize workflows primarily in industrial applications or to help them comply with governmental regulations and industry safety standards. The company’s product lines range from those used on production lines to improve quality and efficiency, to portable systems for rapid and real-time chemical identification in the field or to analyze, measure or respond to hazardous situations.
Production, Process and Analytics includes production line process monitoring and control systems for a range of industrial applications. For example, the company offers on-line instruments that analyze bulk materials non-invasively and in real time to improve quality control and ensure safe operation in a mine or cement manufacturing plant, as well as systems that enable high-speed weighing during bulk materials handling. It also offers gauging systems that employ ionizing and non-ionizing technologies to measure the total thickness, basis weight and coating thickness of flat-sheet materials, such as steel, plastics, foil, rubber and glass. The company also offers on-line analyzers based on various technologies, such as X-ray imaging and ultra-trace chemical detection, to inspect packaged goods for physical contaminants, validate fill quantities, or check for missing or broken parts on-line and at high speeds in the food and beverage, pharmaceutical production and packaging industries, to maintain safety and quality standards.
Field Safety Instruments are rugged handheld products that provide rapid, precise, real-time analysis at the point of need. The company’s main product categories are elemental analyzers, optical analyzers and radiation detection instruments. Its portable elemental analyzers use X-ray fluorescence (XRF) or Laser-induced breakdown spectroscopy technologies in QA/QC applications, to identify metal alloys in scrap metal recycling; in precious metals analysis; in environmental analysis; and for lead screening in a range of consumer products. The company’s portable optical analyzers utilize Raman, Fourier transform infrared (FTIR) and near-infrared (NIR) technologies for use in the field by first responders, and law enforcement and military personnel who need to quickly and accurately identify chemicals and explosives in critical safety and security situations. Other applications include QA/QC in pharmaceutical production and identification of counterfeit drugs. Its radiation measurement products are used to monitor, detect and identify specific forms of radiation in nuclear power, environmental, industrial, medical, and security applications. The company’s primary customers include national, regional, and local government agencies responsible for monitoring cargo, vehicles and people traveling across borders. These products are also used by first-responders in safety and security situations, and for worker safety in the nuclear power and other industrial markets.
Environmental and Process Instruments include fixed and portable instrumentation that help the company’s customers protect people and the environment, as well as comply with government regulations and industry safety standards. Its products are used by environmental regulatory agencies and power plant operators to measure ambient air, and stack gas emissions for compliance with regulated emissions standards for criteria pollutant gases. The company’s products are also used in ambient particulate monitoring applications by customers in mining environments to provide continuous measurements and logging of real-time concentrations and median particle sizes of airborne dust, smoke, mist and fumes.
In addition to its product offerings, the company offers various specialized services to its customers, including equipment servicing, instrument calibration services, asset management and training.
The company’s electron microscopy business includes electron microscopy, molecular spectroscopy and bulk elemental analysis instruments that are used by customers in life sciences, materials sciences, semiconductor and industrial markets to improve breakthrough discoveries.
Electron Microscopy Instruments include transmission electron microscopes which provide imaging and characterization at the atomic scale, with applications in semiconductor development, materials science research and the characterization of protein structure and function. The company also offers scanning electron microscopes, which resolve features from the optical regime down to the nanometer length scale and are used for various applications from materials characterization in science and engineering to applications in natural resources, manufacturing, and biological systems. Its DualBeam focused ion beam-scanning electron microscope systems are used for sample preparation, 3D characterization, nanoprototyping, and industrial failure analysis. The company’s focused ion beam microscopes are used in a range of process control, failure analysis, and materials research applications. It also offers electrical failure analysis instruments, which are used in root cause failure analysis and quality control; microCT instruments, which are micro-computed tomography solutions for quantitative analysis of a range of materials, providing 3D visualization of large volumes non-destructively; and a range of surface analysis instruments commonly used in the semiconductor, metals, coatings, and polymer industries as a product development and failure analysis tool. The company also provides 3D visualization software that turns the data and images generated by a range of instruments into 3D visualizations of the microscopic sample, allowing for the quantitative analysis of material properties.
Molecular Spectroscopy Instruments are divided into four primary techniques, including FTIR, Raman, NIR and ultraviolet/visible spectroscopy. These technologies are used in the laboratory to provide information on the structure of molecules to identify, verify and quantify organic materials in pharmaceutical, biotechnology, polymer, chemical, and forensic sciences. The company’s material characterization instruments include rheometers and extruders that measure viscosity, elasticity, processability, and temperature-related mechanical changes of various materials.
Bulk Elemental Analysis Instruments and analyzers use XRF, X-ray diffraction, and arc spark optical emission techniques for the analysis of bulk materials in the metals, cement, minerals, and petrochemicals industries.
Specialty Diagnostics segment
This segment offers a range of diagnostic test kits, reagents, culture media, instruments and associated products in order to serve customers in healthcare, clinical, pharmaceutical, industrial, and food safety laboratories. This segment has five primary businesses, including Clinical Diagnostics, ImmunoDiagnostics, Microbiology, Transplant Diagnostics and its Healthcare Market Channel.
The company’s clinical diagnostics products include an offering of liquid, ready-to-use and lyophilized immunodiagnostic reagent kits, calibrators, controls and calibration verification fluids. It provides products used for COVID-19 testing; drugs-of-abuse testing; therapeutic drug monitoring, including immunosuppressant drug testing; thyroid hormone testing; serum toxicology; clinical chemistry; immunology; hematology; coagulation; glucose tolerance testing; first trimester screening; tumor markers testing; and biomarkers testing for sepsis, acute myocardial infarction and congestive heart failure. The company also private-labels majority of its reagents and controls for major in vitro diagnostics companies through OEM arrangements. In various instances, the company would work with customers or partners to develop new products and applications for their instrument platforms.
The company has developed one of the major menus for drugs-of-abuse immunoassays. It also provides an offering of immunosuppressant drug immunoassays that could be used on various clinical chemistry analyzers.
The company’s clinical chemistry systems include analyzers and reagents to analyze and measure routine blood and urine chemistry, such as glucose and cholesterol; and advanced testing for specific proteins, therapeutic drug monitoring and drugs-of-abuse. Its diagnostic test range covers approximately 80 different validated methods. The company also provides pre- and post-analytical automation for the preparation of blood specimens before and after analysis, and specialty diagnostic tests based on patented biomarkers for sepsis, cardiovascular and pulmonary diseases, as well as intensive care treatments and prenatal screening.
The company’s immunodiagnostics offerings include developing, manufacturing and marketing complete blood-test systems to support the clinical diagnosis and monitoring of allergy, asthma and autoimmune diseases. It offers antibody tests for approximately 20 indications to help diagnose autoimmune diseases, such as rheumatoid arthritis, celiac disease, lupus and scleroderma. The company’s products include ImmunoCAP for allergy and asthma tests and EliA for autoimmunity tests.
The company’s microbiology offerings include dehydrated and prepared culture media, collection and transport systems, instrumentation and consumables to detect pathogens in blood, diagnostic and rapid direct specimen tests, quality-control products and associated products for the microbiology laboratory. Its products help customers worldwide to diagnose infectious disease; determine appropriate antimicrobial therapy; implement effective infection control programs; and detect microbial contamination of their products or manufacturing facilities.
Within the food and pharmaceutical industries, the company’s products are used to assure the safety and quality of consumer products by monitoring production environments; raw materials and end products for bacterial contamination; and animal health in the dairy industry.
The company’s transplant diagnostics products include human leukocyte antigen (HLA) typing and testing for the organ transplant market. Its diagnostic tests are used by transplant centers for tissue typing, primarily to determine the compatibility of donors and recipients pre-transplant, and to detect the presence of antibodies post-transplant that could lead to transplant rejection. These transplant diagnostic tests are primarily used across the transplant-testing workflow to improve patient outcomes. Its transplant diagnostic offerings include various lines of HLA typing and antibody detection assays utilizing serological, molecular, enzyme-linked immunosorbent assays, flow, and multiplexing technologies.
Healthcare Market Channel
The company’s healthcare market channel offerings include an array of consumables, diagnostic kits and reagents, equipment, instruments, solutions and services for hospitals, clinical laboratories, reference laboratories, physicians’ offices and other clinical testing facilities. These products are manufactured by the company and third parties and are primarily used in clinical diagnosis.
Laboratory Products and Biopharma Services segment
This segment offers various things needed for the laboratory. The company’s combination of self-manufactured and sourced products and service offering enables its customers to focus on their core activities. The segment also includes an offering of outsourced services used by the pharmaceutical and biotech industries for drug development, clinical research, clinical trials services and commercial drug manufacturing. The company serves the pharmaceutical, biotechnology, academic, medical device, government and other research and industrial markets, as well as the clinical laboratory market through five key businesses, such as Laboratory Products, Laboratory Chemicals, Research and Safety Market Channel, Pharma Services and Clinical Research.
The company’s laboratory products are used primarily by pharmaceutical companies for drug discovery and development and by biotechnology companies and universities for life science research to advance the prevention and cure of diseases and improve quality of life. This offering consists of equipment, accessories, and services for sample preparation, storage and protection, and analysis:
Laboratory Equipment Technologies includes the company’s laboratory refrigerators and freezers, ultralow-temperature freezers and cryopreservation storage tanks for maintaining samples in a cold environment to protect them from degradation. The company also offers temperature control products, such as heated bath circulators, immersion coolers, recirculating chillers, water baths, and dry baths in a range of sizes, temperatures and configurations for life science, analytical chemistry, manufacturing and quality-control applications. In addition, it offers sample preparation and preservation equipment, which protects its customers’ chemical and biological samples and supports the growth of cells and organisms in optimal conditions, such as temperature, carbon dioxide and humidity, as well as incubators and related products. The company also offers centrifugation products, which are used to separate biological matrices and inorganic materials, including microcentrifuges, general use bench-top centrifuges and floor models. Additionally, it offers biological safety cabinets, which enable technicians to handle samples without risk to themselves or their environment and without risk of cross-contamination of samples.
Water and Laboratory Products include water analysis instruments such as meters, electrodes and solutions for the measurement of pH, ions, conductivity, dissolved oxygen, turbidity and other key parameters in the lab and production line. The company also offers other laboratory equipment such as water purification systems, shakers, vacuum concentrators, microbiological incubators, ovens, furnaces, hotplates, stirrers, stirring hotplates, and other related products.
Laboratory Plastics Essentials include an offering of laboratory pipette tips and a complementary range of handheld and automated pipetting systems, supporting low-through high-throughput activity. These products optimize productivity and ergonomics, and ensure results. The company also offers sample preparation and storage products, such as centrifugation consumables, as well as vials and organization systems for ultralow temperature and cryogenic storage, with specific products designed for low protein binding and low DNA binding and containers for packaging life science and diagnostic reagents as well for the storage and transport of bulk intermediates and active pharmaceutical ingredients. Additionally, the company’s offerings include a selection of clinical specimen collection products, drug-of-abuse collection kits and environmental and food-safety glass and plastic vials, bottles and containers, plastic transfer pipettes, general purpose clinical laboratory consumables and containers for breast milk collection, storage and feeding primarily used in neo-natal units and by lactation specialists. The company also provides OEM and custom kit assembly services for clinical and drugs-of-abuse test kits.
The company’s laboratory chemicals offering comprises a range of chemicals, solvents and reagents supporting various laboratory applications – from research to drug discovery and development and manufacturing. This portfolio includes organic chemicals used to synthesize new materials; essential laboratory chemicals used by scientists to purify, extract, separate, identify and manufacture products; high-purity analytical reagents, bioreagents used in various applications, from cell growth to detailed protein analysis; novel chemical building blocks, reactive intermediates and screening libraries used to accelerate drug discovery; and precious metals, salts and solutions used in a range of applications where highly specific reactions are desired. The company provides bulk volumes of many products for scale-up from research to development and customized services for chemical procurement, processing, production, testing, and packaging.
Research and Safety Market Channel
The company’s research and safety market channel serves academic, pharmaceutical, biotechnology, government and industrial customers. The company goes to market through its sales force, segment-relevant printed collateral and digital content in four languages, a website, www.fishersci.com, containing full product content for approximately 1.5 million products, and its global network of resellers and distributors.
The company has an international network of warehouses in its primary markets through which it maintains inventory and coordinate product delivery. With specialized product vaults and warehouse management systems, the company is able to handle the range of products it offers to its customers. The company’s transportation capabilities include its fleet of delivery vehicles, as well as parcel shipping capabilities that are integrated with its third-party parcel carriers. Throughout the product delivery process, the company provides its customers with convenient access to electronic systems that offer automated catalog search, product order and invoicing, and payment capabilities. The company’s channel offers a mix of products that are manufactured by it, by third parties for the company on a private-label basis, and by third parties under their brand but offered for sale exclusively through the company. It also offers a range of third-party products representing various brand names on a non-exclusive basis.
The company’s research products include an offering of laboratory products, ranging from capital equipment and instruments to chemicals to consumable products. Its safety products include clean-room and controlled-environment supplies, personal protective equipment, firefighting, military, and first responder equipment and supplies, and environmental monitoring and sampling equipment. The company’s education products include science-related and laboratory products for the K-12 and secondary education markets. In addition to its product offerings, the company offers various specialized services to its customers through its Unity Lab Services team, including training, equipment servicing and asset management, and supply management personnel. The company also offers scientific support services, including desktop delivery, coordination of instrument calibration and service, and on-site customer service.
The company provides the spectrum of development, manufacturing and clinical trials services for both small-molecule and large-molecule pharmaceuticals. This includes development of a suitable formulation and manufacturing process for the active pharmaceutical ingredient (API) or biologic; technology transfer to scale up the manufacturing; labeling, packaging, distribution and logistics for clinical trials; and commercial scale manufacturing and packaging.
Drug Substance Services: The company’s service offerings address small molecules, produced through chemical synthesis, and large molecules such as antibodies and proteins produced through mammalian cell culture. It provides development and manufacturing services for small molecule APIs and the biologically active component of pharmaceutical products under cGMP conditions from early development through commercial production. The company also provides a range of viral vector development and manufacturing services for customers developing and commercializing gene and cell therapies, including process development, optimization, scale-up, the analytical development and qualification of viral vectors for commercial manufacturing. Its breadth of vector platform includes the five major used virus types, providing coverage across the gene and cell therapy landscape.
Drug Product Services: The company manufactures both small-molecule and large-molecule products for customers in conventional and specialized dosage forms. The company provides various formulation, production and technical services and scientific focus and solutions, from the early stages of a product’s development to regulatory approval and commercial scale production.
Clinical Trials Services: The company provides a comprehensive global supply chain offering for pharmaceutical and biotechnology companies engaged in clinical trials, including comparator sourcing; specialized packaging; over-encapsulation; multi-lingual and specialized labeling and distribution for phase I through phase IV clinical trials; biological-specimen management and biobanking services; specialty pharmaceutical logistics; clinical supply-chain planning and management; and a global distribution logistics network.
Advanced Therapy Services: The company provides a global network of cell and gene therapy development, manufacturing and supply chain services for Plasmid, mRNA drug substance and cell therapy manufacturing.
The company offers integrated clinical development and analytical services to its biopharmaceutical, biotechnology, government and academic customers. Its clinical development services include various phases of development (i.e., Phases I-IV), peri- and post-approval and site and patient access services. The company’s analytical services include a range of testing services, including bioanalytical, biomarker, vaccine, cGMP and central laboratory services.
Clinical Development Services: Within the company’s clinical development services business, it provides early development and clinical research management services, site and patient access services, and peri- and post-approval services.
The company, through its early development and clinical research management services offering, provides comprehensive support to early clinical development programs, including Phase I trials. It conducts early-phase studies at its dedicated in-patient clinical facilities and complement these Phase I clinical research units with a global network of affiliated clinical trial sites. The company also provides full-service protocol management for Phases II-IV clinical research studies for investigational new drugs, biologics and medical devices. Its suite of services for Phases II-IV clinical trials includes protocol design; clinical trial strategic feasibility and investigator site selection; project management; site study startup activities; patient recruitment; clinical monitoring and data capture; data management; biostatistics; safety medical monitoring/pharmacovigilance; regulatory affairs; medical writing; global clinical supplies; eClinical services; quality assurance; and virtual and digitally enabled trial solutions.
The company, through its site and patient access services offering, combines its industry patient recruitment capability with an independent network of clinical research investigator sites to offer services to complement the traditional site selection model, speeding study enrollment through centralized recruitment, while leveraging its network sites exclusively or in conjunction with independent investigators.
The company, through its peri- and post-approval services offering, provides real-world research and evidence-based solutions to demonstrate the value of biopharmaceutical and biotechnology products. The company also provides industry inbound and outbound peri- and post-approval contact center solutions focused on medical and clinical support to the biopharmaceutical industry.
Analytical Services: The company owns and operates an integrated and scaled suite of laboratory services. Its bioanalytical laboratories analyze drug and metabolite concentrations from biological fluid and tissue samples within preclinical and human clinical studies. The company’s biomarker laboratory is aligned with both the central laboratories and bioanalytical laboratories to provide customized solutions for biomarker projects, including ligand binding, flow cytometry and molecular genomics. The company also performs testing for vaccines, such as immunogenicity testing to evaluate the efficacy of vaccines in inducing cellular and humoral immune responses, and employ molecular detection methods, such as polymerase chain reaction testing to detect the absence of pathogens or to characterize attenuated vaccine strains following administration of a vaccine. The company provides early preclinical development through post-approval testing services and product analysis laboratory services that are designed to be compliant with cGMPs, and its central laboratories provide standardized safety and biomarker testing services with customized results databases for its customers.
In January 2021, the company acquired, within the Laboratory Products and Biopharma Services segment, the Belgium-based European viral vector manufacturing business of Groupe Novasep SAS.
In February 2021, the company acquired, within the Life Sciences Solutions segment, Mesa Biotech, Inc., a U.S.-based molecular diagnostic company.
In December 2021, the company acquired, within the Laboratory Products and Biopharma Services segment, PPD, Inc., a U.S.-based global provider of clinical research services to the pharma and biotech industry.
In December 2021, the company acquired, within the Life Sciences Solutions segment, PeproTech, Inc., a U.S. based developer and manufacturer of recombinant proteins.
Sales and Marketing
The company markets and sells its products and services through a direct sales force, customer-service professionals, electronic commerce, third-party distributors, and various catalogs. It offers its products and services through various brands, including:
The Thermo Scientific brand offers customers in research, diagnostics, industrial, and applied markets a range of analytical instruments, as well as laboratory equipment, software, services, consumables and reagents. The company’s portfolio of products includes technologies for mass spectrometry, chromatography, elemental analysis, electron microscopy, molecular spectroscopy, sample preparation, informatics, chemical research and analysis, cell culture, bioprocess production, cellular, protein and molecular biology research, allergy testing, drugs-of-abuse testing, therapeutic drug monitoring testing, microbiology, as well as environmental monitoring and process control.
The Applied Biosystems brand offers customers in research, clinical and applied markets integrated instrument systems, reagents, and software for genetic analysis. The company’s portfolio includes technologies for genetic sequencing and real-time, digital and end point PCR, which are used to determine meaningful genetic information in applications, such as COVID-19 testing, cancer diagnostics, human identification testing, and animal health, as well as inherited and infectious disease.
The Invitrogen brand offers life science customers a broad range of consumables and instruments that accelerate research and ensure consistency of results. The company’s portfolio of products includes solutions for cellular analysis and biology, flow cytometry, cell culture, protein expression, synthetic biology, molecular biology and protein biology.
Fisher Scientific is the company’s channels brand, offering customers a portfolio of laboratory equipment and consumables, chemicals, supplies and services used in scientific research, healthcare, safety, and education markets. These products are offered through a network of direct sales professionals, segment-relevant printed collateral and digital content, a website, and supply-chain management services.
Unity Lab Services is the company’s instrument and equipment services brand, offering a portfolio of services from enterprise level engagements to individual instruments and laboratory equipment, regardless of the original manufacturer.
Patheon is the company’s contract development and manufacturing brand, representing the offering of services that it provides to customers ranging from small biotech to large pharmaceutical companies. The company supports its customers’ development of medicines, including biologics, gene therapies and vaccines. By leveraging its global network of facilities, the company delivers services at all stages of the drug lifecycle, from discovery to development through clinical trials and commercial manufacturing.
PPD is the company’s clinical research services brand, helping customers in the biopharmaceutical industry bring their medicines and other treatments to patients worldwide. Its clinical development services include various phases of development (i.e., Phases I-IV), peri- and post-approval and site and patient access services. The company’s analytical services offer a range of advanced testing services, including bioanalytical, biomarker, vaccine, cGMP and central laboratory services.
The company has approximately 15,000 sales personnel, including highly trained technical specialists who enable it to meet the needs of its technical end-users. The company also provides customers with product standardization and other supply-chain-management services.
The company’s revenues in the fourth quarter (year ended December 2021) are historically stronger than in other quarters due to the capital spending patterns of industrial, pharmaceutical and government customers. The sale of flu tests and related diagnostic products vary quarter to quarter and year to year based on the severity and duration of each period’s flu season. The sale of allergy tests vary quarter to quarter and year to year based on the severity and duration of each period’s airborne pollen allergens.
The U.S. federal environmental legislation that affects the company includes the Toxic Substances Control Act, the Resource Conservation and Recovery Act, the Clean Air Act, the Clean Water Act, the Safe Drinking Water Act, and the Comprehensive Environmental Response Compensation and Liability Act.
The company is also subject to regulation by the Occupational Safety and Health Administration concerning employee safety and health matters. The United States Environmental Protection Agency, the Occupational Safety and Health Administration, and other federal agencies have the authority to promulgate regulations that have an effect on the company’s operations.
The company’s Fair Lawn and Somerville, New Jersey facilities entered into administrative consent orders with the New Jersey Department of Environmental Protection in 1984 to maintain groundwater-remediation activities at these sites; and are under the State’s Licensed Site Remediation Professional Program.
As the owner of the Fair Lawn facility, the company is listed as a potentially responsible party for remediation within an area called the Fair Lawn Wellfields Superfund Site. In 2008, the company and certain other parties entered into a consent order with the U.S. Environmental Protection Agency to complete a Remedial Investigation/Feasibility Study. In 2011, the company’s Life Technologies subsidiary entered into a consent decree with the U.S. Environmental Protection Agency and other responsible parties to implement a groundwater remedy at the former Davis Landfill Superfund site in Smithfield, Rhode Island.
The company’s operations, and some of the products that it offers, are subject to various laws and regulations governing the production, handling, transportation and distribution of chemicals, drugs and other similar products, including the operating and security standards of the Food and Drug Administration; the Drug Enforcement Administration; the Bureau of Alcohol, Tobacco, Firearms and Explosives; and various state boards of pharmacy, as well as comparable state and foreign agencies.
As the company’s businesses also include export and import activities, the company is subject to pertinent laws enforced by the U.S. Departments of Commerce, State and Treasury. In addition, the company’s logistics activities must comply with the rules and regulations of the Department of Transportation, the Federal Aviation Administration, and similar foreign agencies.
Thermo Fisher Scientific Inc., a Delaware corporation, was incorporated in 1956.